Consortium International

This approach has allowed us to verify that each tumor has suffered some 1,000 mutations in their genome, clarifies Carlos Lopez-Otin. Subsequent analysis of genes mutated in a group of more than 300 patients allowed us to identify four genes whose mutations lead to the development of this type of leukemia, reveals the researcher. Advances in the knowledge of the molecular biology of cancer during the past few decades have allowed to determine that it is a disease caused by the accumulation of genetic damage in normal cells, but until now the identification of those changes was a process slow and laborious. However, thanks to the latest equipment for the sequencing of genomes, such as those available to scientists at the National Center for Genomic analysis, this process has accelerated, and in this Center can be currently sequence up to six human genomes in one day. A Spanish research analysis of the extraordinary volume of data generated in this project has required the creation of specialized programs. Sidron is the name of the computer tool developed at the University of Oviedo and that has been essential to identify the mutations present in tumor genomes. The work of several decades in the Hospital Clinic of Barcelona in leukemia lymphatic Chronicle has allowed the consortium have DNA and clinical data of hundreds of patients, who have contributed an additional clinical dimension to this genomic study. The Spanish Consortium for the study of the genome of the leukemia lymphatic Chronicle (CLL Genome) is funded by the Ministry of science and innovation, through the Instituto de Salud Carlos III, and is part of the Consortium International the genomes of Cancer, led by Dr. Tom Hudson of the Research Institute of Ontario (Canada) Cancer. Source of the news: Spanish scientists decode genome of the chronic lymphatic leukaemia, the most common

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